Vidya Prasarak Mandal's

ADVANCED STUDY CENTRE

C/o. B. N. Bandodkar College of Science, Thane (W). 400601.

E-mail: vpmt@vsnl.net   Tel. No.: 022 – 25339871           URL: www.vpmthane.org

 

POST GRADUATE DIPLOMA IN APPLIED ANALYTICAL CHEMISTRY

 

 

 

SYLLABUS

 

PAPER – I: Fundamentals of Analytical Chemistry and Legal Aspects  (100 marks)

 

1: Errors, Precision and Accuracy

1.1   Introduction

1.2   Types of errors

1.3   Precision and accuracy

1.4   Method of expressing accuracy

1.5   Methods of expressing precision

 

2: Statistical Quality Control

 

3: Calibration

Calibration of burette, pipette, graduated pipette & standard volumetric flask using monopan balance

 

4: Introduction to Analytical Chemistry & Basic Physio Chemical Principles

4.1 Basic principles, current voltage, curve with polarization, factors affecting the current

       voltage curve- residual current, migration current, diffusion current

4.2 Working of polar-graphic unit having dropping mercury electrode, stripping method,

       differential pulse polarography

4.3 Applications

 

5: Potentiometric Titration & Volumetric Analysis

5.1 Introduction to potentiometric titration

5.2 Instrumentation

5.3 Types of potentiometric titration

5.4 Advantages of potentiometric titration

5.5 Introduction to volumetric analysis

5.6 Acid base titration, Redox titration, Complexometric titration, Aqueous titration

 

6: Solvent Extraction & Separation Techniques

6.1   Introduction

6.2   Extraction methods

6.3   Extraction techniques

6.4   Applications

 

7: Limit Tests

7.1 Specificity and sensitivity of limit test

7.2 Limits of moisture, volatile matter and residual solvents

7.3 Limits of residue on drying

7.4 Limit test for metallic impurities

7.5 Determination of moisture content by Karl Fischer method

 

8: Introduction to Legal Aspects

8.1 Sampling in chemical industry

8.2 Quality Assurance (QA)

8.3 Introduction to current Good Manufacturing Practices (GMP)

8.4 Quality Control (QC)

8.5 Good Laboratory Practices GLP

8.6 Introduction to ISO, ISO 9000 and ISO 14000

8.7 Total Quality Management

8.8 Kaizen principles

8.9 Introduction to various Laws related chemical industry

8.10 Introduction to packaging material testing

8.11 Industrial methods of development and validation

 

PAPER – II: Instrumental Methods of Chemical Analysis (100 marks)

 

1: Infrared Absorption Spectroscopy

1.1   Theory of Infrared Absorption Spectroscopy

1.2   Instrumentation (Double beam spectrophotometer)

1.3   Modes of vibration and factors influencing vibrational frequencies

1.4   Sampling techniques

1.5   Position and intensity of bands

1.6   Applications of Infrared Spectroscopy

 

2: Colorimetry, Ultraviolet and Visible Spectroscopy

2.1 Theory of Colorimetry, Ultraviolet and Visible Spectroscopy

2.2 Instrumentation

2.3 The concept of Auxochrome and Chromophone

2.4 Effect of conjugation and solvent effect

2.5 Woodword-Feiser rules for calculating absorption maxima

2.6 Applications – qualitative and quantitative

 

3: Nuclear Magnetic Resonance Spectroscopy (NMR)

3.1 Introduction

3.2 Rules predicting spin number of Nuclei and calculation of spin numbers

3.3 Number of signals, Chemical Shift of different types of protons coupling constant (J)

3.4 Spin-spin coupling, Splitting of signals

3.5 Interpretation of NMR spectroscopy

 

4: Mass Spectrometry

4.1 Theory and basic principles

4.2 Instrumentation

4.3 Metastable ions or peaks

4.4 General fragmentation modes

4.5 Typical examples of interpretation of mass spectra

 

5: Flame Photometry

5.1 Principles of Flame Photometry

5.2 Instrumentation

5.3 Effect of solvent in Flame Photometry

5.4 Interferences in Flame Photometry

5.5 Limitations and applications of Flame Photometry

 

6: Atomic Absorption Spectroscopy (AAS)

6.1 Principles and Instrumentation

6.2 Detections of non-metals by AAS

6.3 Difference between Atomic Absorption Spectroscopy & Flame Emission

       Spectroscopy

6.4   Detection limit and sensitivity

6.5   Applications and disadvantages of AAS

 

7: Nephelometry and Turbidimetry

7.1 Introduction and Instrumentation

7.2 Theory

7.3 Comparison between Nephelometry and Turbidimetry

7.4 Applications

 

8: Thermal Analytical Methods

8.1 Introduction

8.2 Differential Thermal Analysis (DTA)

8.3 Differential Scanning Colorimetry (DSC)

8.4 Factors affecting thermal methods

 

9: Gas Chromatography (GC)

9.1 Principles of GC separations

9.2 Instrumentation

9.3 Selection of and various types of columns

9.4 Methods of analysis

9.5 Applications - qualitative and quantitative

9.6 Limitations of GC

 

10: High Performance Liquid Chromatography (HPLC)

10.1 Principles of HPLC

10.2 Instrumentation

10.3 Column efficiency and selectivity

10.4 Applications

10.5 Comparison between GC and HPLC

 

11: Column Chromatography

11.1 Introduction

11.2 Theory and Principles

11.3 Column efficiency

11.4 Applications of column chromatography

 

 

 

PAPER – III Environment Science and Laboratory Safety  (100 marks)

 

1: Water

1.1   Sources of water

1.2   Impurities in water

1.3   Requirements of potable / drinking water

 

2: Technical (Theoretical) Aspects of Water Analysis

2.1 Estimation of total solid, oil and greases, determination of total alkalinity & sulphate

2.2 Estimation of total hardness

2.3 Estimation of Dissolved Oxygen (DO) by Wrinkler Method

2.4 Estimation of Chemical Oxygen Demand (COD)

2.5 Estimation of Biological Oxygen Demand (BOD)

 

3: Purification of Water

3.1 Removal of Micro-organism

3.2 Removal of hardness of water

3.3 Lime sods process

3.4 Zeolite

3.5 Ion-exchange, Deionization and De-mineralization process

 

4: Air

     4.1 Composition of air

     4.2 Air pollutants

     4.3 Impact of air pollution on environment

     4.4 Air pollution analysis and monitoring

     4.5 Remedial measures

 

5: Introduction to Soil Analysis

 

6: Safety in Laboratory

6.1 Fundamental of Safety

6.2 Fire Hazards

6.3 Static and Current Electricity

6.4 Occupational Safety, First Aid and Risk Management

6.5 Safety of Chemicals

6.6 Personnel Protective Equipments

6.7 Material Safety Data Sheet MSDS

6.8 Fundamentals and Regulations pertaining to Safety

6.9 Physical & Physiological Factors influencing safety

6.10 Engineering techniques for accident prevention

6.11 Emergency Management

6.12 Process Safety